One cannot determine advanced lung cancer by right shoulder pain, and multiple factors can cause shoulder pain. In order to know the condition of lung cancer, according to clinical symptoms and examination results, patients should do imaging examination of chest such as CT, examination of tumor markers, blood routine and examination on respiratory function. In the advanced stage of lung cancer, patients may show sitting breathing, chest tightness, shortness of breath, dyspnea, and metastatic symptoms, such as neurological metastasis, liver metastasis, bone metastasis and so on. Right shoulder pain may be caused by cold, bruise, overwork, frozen shoulder and so on, and it is not possible to understand lung cancer by shoulder pain, but patients with right shoulder pain with symptoms of dyspnea, chest pain, coughing and spitting should actively consult doctor to understand their condition and follow standardized treatment, so as not to be negligent to avoid delaying their condition.