Caused by the corners of the mouth blisters for more reasons, different cases of treatment is not the same, there are the following aspects of the cause: 1, fire, due to too little water intake, the body of yin and yang imbalance caused by the symptoms of internal heat, the patient can drink more water, you can take Sanshuang tablets, cephalosporins for treatment; 2, lack of vitamins, the most common lack of vitamin B2 caused by the supplementation of medication Vitamin B2, but also can eat bananas, Oranges, pears, kiwi, animal liver, egg yolk, etc.; 3, herpes stomatitis, caused by herpes simplex virus infection, patients can use acyclovir, interferon for antiviral treatment; 4, stomatitis, due to malnutrition, riboflavin deficiency, infection and other causes of this symptom, patients can eat a variety of nutrient-rich foods, take multivitamins, can also be taken orally penicillin drugs, roxithromycin. Localization can be applied with glycerite lotion, erythromycin ointment.