Whether you can stop taking entecavir for 4 years should be determined by what state you were in before taking the drug. If you were in a compensated or decompensated stage of cirrhosis before taking the drug, entecavir should be taken for life. If you were not in cirrhosis but in major triplet before taking the drug, and if you have changed to minor triplet soon after taking the drug, and the duration of minor triplet has been more than 3 years and the DNA has also been negative for 3 years, you can consider stopping the drug carefully. If the patient was a minor triplet before taking the medication and the surface antigen is still (+), the medication cannot be stopped because it may cause virological rebound after stopping the medication, liver function abnormalities may occur, and in a very small number of patients, severe hepatitis may be induced. Therefore, the decision of whether to stop the medication or not is not based on the length of time the patient has been taking the medication, but on the disease status before taking the medication and the efficacy after taking the medication.