It is recommended to drink plain water when taking entecavir clinically, and if tea is to be consumed only a small amount of clear tea; strong tea can interfere with the metabolism of entecavir. Entecavir is generally consumed on an empty stomach and should not be mixed with food. The role of entecavir is mainly to inhibit the replication of hepatitis B virus, usually in 3-6 months after taking the drug hepatitis B virus can turn negative, if oral entecavir 3-6 months did not appear to decline or turn negative hepatitis B virus, it is necessary to switch to tenofovir for treatment. Entecavir and tenofovir are the first-line antiviral drugs recommended by the current guidelines for the prevention and treatment of hepatitis B. They can not only inhibit the replication of hepatitis B virus, but also delay the development of liver fibrosis and cirrhosis, but cannot completely remove the hepatitis B virus from the blood, so hepatitis B patients usually need to take antiviral drugs for a long time.