Men urinary orifice ulceration is mostly caused by bacterial infection, herpes virus infection, syphilis spirochete infection, can use antibacterial drugs, antiviral drugs, antisyphilis drugs for treatment. 1. Urethral ulcers caused by bacterial infection: you can take oral penicillin drugs, cephalosporins, macrolides, quinolones for treatment, such as amoxicillin, cefuroxime, erythromycin ethylsuccinate, ciprofloxacin and so on. Erythromycin ointment and mupirocin cream can also be applied locally. 2. Urethral ulceration caused by herpes virus infection: anti-viral drugs can be used, such as oral acyclovir tablets, vasiclovir tablets, or topical acyclovir ointment. 3. Urethral ulceration caused by syphilis spirochete infection: preferred penicillin drug treatment, such as benzylpenicillin, benzylpenicillin, penicillin allergy, tetracycline, macrolides, such as doxycycline, azithromycin and so on. These drugs have different degrees of adverse reactions, such as dizziness, nausea, vomiting, rash, skin irritation, etc. They must be used under the guidance of a doctor in strict accordance with medical advice.