Serum-bound globulin is a glycoprotein synthesized by the liver, which can mainly bind to hemoglobin in plasma to form a stable complex, and its measurement mainly reflects whether there is a possibility of hemolysis in the patient’s body. The increase of serum conjugated globulin is usually found in patients with connective tissue system diseases, such as systemic lupus erythematosus or steroid drugs, as well as biliary obstruction, trauma, neoplastic diseases, and pregnancy, oral contraceptive pills, etc., which can produce the increase of serum conjugated globulin in patients. In addition, the decrease of serum conjugated globulin is most often seen in patients with hemolysis, which is the most common condition. In addition, there are hepatocellular lesions, including patients with viral hepatitis or hepatitis caused by other diseases, such as alcoholic hepatitis or drug-related hepatitis. Some patients may have reduced serum lipoproteins due to congenital factors, as well as patients with other hematologic disorders, which may also cause a reduction in serum-bound globulin. In this case, patients need to check peripheral blood smear for abnormal blood cells if necessary, as well as bone marrow aspiration if necessary.