Itchy hands after taking misoprostol may be caused by drug allergy. If the itchy hands are not serious, you can continue to observe without special treatment. If the symptoms of itchy hands do not get better, on the contrary, aggravated, it is recommended to stop using the drug again in time, and under the guidance of the doctor to use some anti-allergy drugs. After the application of misoprostol common adverse reactions are mainly gastrointestinal reactions, with the oral dosage has a clear relationship, such as abdominal pain, diarrhea, most of the impact is not significant, there are some other mild headache, fatigue, a very small number of women may have a rash, itching, but there is no need to be overly nervous, worried. When applying misoprostol you should inform your doctor if you have ever had a history of prostaglandin allergy or glaucoma, asthma and allergies, in which case misoprostol is not recommended.