The thickening of echogenicity in the liver and roughness of the gallbladder wall may be related to viral hepatitis, fatty liver and cirrhosis, resulting in hepatocyte damage, degeneration, necrosis, diffuse steatosis, bacterial infections, or affecting the secretion of bile acids in combination with chronic cholecystitis, and so on. 1. In patients with viral hepatitis, viral or bacterial infection may lead to thickening of liver echogenicity after hepatocyte damage. If bacterial invasion leads to cholecystitis, the wall of the gallbladder may also be found to be rough during ultrasound examination. 2. For people with fatty liver due to obesity or abnormal lipid metabolism, excessive fat deposition in liver cells or diffuse steatosis of liver cells may lead to thickening of liver echoes during ultrasound examination. Patients with fatty liver affect the bile acid secretion, and if it leads to imbalance of bile acid ratio, it may be combined with cholecystitis, resulting in thickening of the gallbladder wall. 3. In patients with type B viral hepatitis or fatty liver or alcoholic liver that further develops and leads to cirrhosis, liver cell degeneration, necrosis and fibrous tissue proliferation will lead to thickening of intrahepatic echogenicity. Cirrhotic patients with increased inflammation or abnormal bile acid metabolism may develop cholecystitis, resulting in thickening of the gallbladder wall. Ultrasound examination found thickening of intrahepatic echoes, gallbladder wall thickening, if the patient has right upper abdominal pain, nausea, anorexia and other symptoms, should be promptly to the hospital for examination and treatment.