Infants with fever and cold hands and feet can be treated with medicines such as Pediatric Heat Quickly Clear Oral Liquid, Qingpaixiehuanyu (clearing away heat and toxins) Pill, and Pediatric Huanxie Pill, depending on the cause of the illness. Cold hands and feet in infants with fever is a common accompanying symptom of fever. 1. Pediatric Heat and Clear Oral Liquid: Pediatric Heat and Clear Oral Liquid can be chosen for infants with fever due to exogenous wind-heat, it has the effect of clearing heat and removing toxins (removing heat and toxins from the body), diaphoretic effect, clinically used for children’s colds caused by exogenous wind-heat, symptoms such as headache, fever, sore throat, etc.. The adverse reactions and contraindications of pediatric heat fast clear oral solution are not clear. 2. Qingpian detoxification pills: infants can choose Qingpian detoxification pills for fever due to the feeling of dampness and heat, with the efficacy of Qingpian detoxification, can be used for external infection, thirst and dry throat, big head of the plague, mumps, abhorrence of cold and strong heat. The adverse reactions and contraindications of Qingpiedu Xieyu Pian are not clear. 3. Pediatric Hwa Sai Wan: When infants have fever due to gastrointestinal stagnation, pediatric Hwa Sai Wan can be chosen, which has the efficacy of diarrhea and laxative, eliminating food and stagnation, and can be used for stagnation caused by stagnation of food and stagnation of food and heat, which can be seen in epigastric (abdominal) distension and fullness, irritability, and dryness of stools. The adverse reactions and contraindications of Xiaoyi Huanji Pill are not clear, and a light diet is required during the administration of the drug. Infants with fever, should seek medical diagnosis for standardized treatment, the above drugs need to be taken under the guidance of a traditional Chinese medicine practitioner, avoid self-medication.