What are the side effects and dangers of long-term insulin injections? Insulin therapy is the most important drug in the treatment of type 1 diabetes. Regardless of acute and chronic complications, lifelong insulin replacement therapy is required and cannot be terminated abruptly. So, what are the side effects and hazards of long-term insulin injections? 1.Pain The pain caused by insulin injection is very mild. The pain caused by injection is related to the following factors: ① pain is related to the injection site, among which the pain of abdominal injection is the lightest, easy to inject, no need to undress and take off pants, most suitable for injection in winter and when working outside; ② if the pain is obvious in a certain injection, it is possible that the needle touches the subcutaneous nerve, attention should be paid to the choice of injection site; ③ factors such as slow needle speed, blunting of the needle for a long time and mental tension can also aggravate Pain. 2, skin infection Serious infection is rare, but the injection site “red spot” is more common, and the skin is unclean, aseptic operation during injection is not strict. 3, subcutaneous bruising caused by injury to the subcutaneous capillaries during injection, do not inject here before the bruising is absorbed. Generally, it can be absorbed on its own after a week and does not require special treatment. 4.Fat pad As insulin is injected in the same area for a long time, it can stimulate subcutaneous fat hypertrophy and form fat pad or nodule, and if insulin is injected in the fat pad area, it will affect its absorption. 5. Weight gain After insulin injection, it often causes abdominal obesity, which is common in elderly diabetic patients. Type II diabetic patients with human insulin plus metformin hypoglycemic yao, can reduce obesity. 6, insulin resistance Commonly seen in type II diabetic patients with obesity and large insulin dosage, in the absence of ketoacidosis, daily insulin dosage greater than 200 units and lasting for more than 48 hours can be diagnosed as insulin resistance yao. 7.Insulin overflow When the needle is removed after insulin injection, a small amount of insulin will flow out from the eye of the needle, resulting in inaccurate insulin dosage. When using Novo Pen injection, this situation is more common. The correct method is: pinch up the skin when injecting and enter the needle at an angle of 45 degrees, if the dosage is large, inject it in several times, and inject it once if the amount is small. Wait 1 minute after the injection and then dial the needle, there will be no insulin spillage. 8. Refractive error Most often occurs after the initial insulin treatment, due to the rapid decline in blood sugar, causing changes in the osmolarity of the lens and vitreous humor, resulting in a decrease in refractive index and blurred vision due to water overflow in the lens, which generally heals itself in 2-4 weeks. 9, insulin antibodies Long-term use of animal insulin can cause the body to produce insulin antibodies, affecting the absorption of insulin and hypoglycemic effect. If the insulin release test is performed, the insulin measurement value may become low, resulting in inaccurate results. Changing to human insulin and insulin analogues can reduce the formation of antibodies. 10.Insulin edema Before diabetes is controlled, high blood sugar can lead to water loss, sodium loss and reduction of extracellular fluid in the body. When receiving insulin therapy, within 4-6 days after the blood sugar is effectively controlled, water and sodium retention can occur in the body, and edema of the face and limbs, which can generally be absorbed by itself within a few days. Edema in different parts of the body can occur when the initial injection dose of insulin therapy is large, but it can often disappear on its own with the continued use of insulin. The above is the side effects and hazards of long-term insulin injection, I hope you understand, insulin is not the best way to treat diabetes, and will bring side effects to patients, the current tendency of excessive insulin use, so it is recommended that the dosage of insulin ” 60U patients, should find a doctor to adjust the amount of insulin, add some oral medication to reduce the amount of insulin.