After a day of missed doses of entecavir, there is usually no need to make up the dose, but care should be taken to avoid similar situations, and later attention should be paid to taking the medication on time and in a standardized manner. Entecavir is a guanine nucleoside analog, which has an inhibitory effect on the hepatitis B virus (HBV) polymerase, and is usually used to treat chronic hepatitis B. Entecavir should be taken as prescribed by the doctor, and if you feel muscle soreness, pain or fatigue after taking it, you should contact your physician promptly. Before stopping or changing the dose should listen to the physician’s advice, if you forget to take the medicine in a fixed period of time, you can make up for it within an interval of 12 hours, if the interval is more than 12 hours, you can just take the next dose directly, do not double the dose. If you forget to take the medication two or three times in a row, it is easy to cause viral rebound, drug resistance and other occurrences, and you need to contact your physician immediately for treatment. In addition, the incidence of drug resistance of entecavir is relatively low, if drug resistance occurs, you can follow the doctor’s advice to change to tenofovir or propofol tenofovir according to the situation. In particular, patients with decompensated liver function and cirrhosis should not stop taking the drug easily. Patients’ medication should be adjusted according to the specific situation in order to reduce adverse drug reactions and achieve better therapeutic effects.