Keratosis Pilaris may be associated with heredity, chronic friction, fungal infections, and hand and foot dermatoses. 1. Heredity: born with the gene for this disease, it is common that most people in a family or a family are suffering from this disease. 2. Long-term friction: Long-term friction leads to thickening of the cuticle and callus, which in turn leads to keratinization. 3. Fungal infection: when the skin is infected by fungi, ringworm and tinea pedis can appear, and the phenomenon of keratinization of hands and feet can occur. 4. hand and foot skin disease: such as keratosis pilaris, palm and metatarsal chronic eczema, etc., the skin disease is not cured for a long time, resulting in thickening of the keratin or cracking of the hand and foot parts, which can form hand and foot keratosis pilaris. It is recommended that people with keratosis pilaris go to the regular hospital in time, to clarify the cause of the disease, under the guidance of the doctor for standardized treatment.