The most important treatment for septic arthritis is symptomatic treatment such as anti-infection, joint cavity irrigation and arthroscopy. Broad-spectrum antibiotics such as cephalosporins (e.g. ceftriaxone) or penicillins (piperacillin) can be used empirically before bacterial culture, and after the results of pus culture and drug sensitivity analysis are available, the appropriate sensitive antibiotic (e.g. cefoperazone) can be selected for targeted treatment. Septic arthritis is a type of arthritis that is directly infected by purulent bacteria and causes joint destruction and loss of function, also known as bacterial arthritis or septic arthritis. After the diagnosis of septic arthritis is confirmed, a puncture of the joint cavity may be performed to extract pus, which is subjected to bacterial culture and drug sensitivity analysis. When the results of the drug sensitivity analysis have not yet been returned, you can choose cephalosporins such as ceftriaxone and cefazolin, or penicillin antibiotics such as piperacillin and other broad-spectrum antibiotics for anti-infective treatment based on experience. When the results of drug sensitivity analysis are returned, a suitable sensitive antibiotic (e.g., cefoperazone, etc.) can be selected for targeted treatment. If septic arthritis continues to worsen after anti-infective treatment, continuous irrigation of the joint cavity or even arthroscopic treatment may be considered. If septic arthritis occurs, it is recommended to treat it as soon as possible under the guidance of orthopedic surgeons to avoid serious sequelae such as osteonecrosis due to untimely treatment.