The majority of male syphilis chancre occurs on the external genitalia. The chancre of syphilis is a manifestation of painless ulcers on the skin and mucous membranes after the patient has been infected with the spirochete syphilis. Syphilis is a chronic, systemic sexually transmitted disease (STD) that is mainly transmitted through sexual contact, mother-to-child transmission and blood transmission. After a male patient is diagnosed with syphilis, a hard chancre may appear on the penis, glans, foreskin, ligament and other parts of the body at an early stage, manifesting itself as a small red spot or pimple, followed by the formation of a round or oval painless ulcer. It is recommended that if the above symptoms occur, patients should go to the dermatology and venereal diseases department or the infection department of regular hospitals in time, follow the doctor’s instructions to clarify the diagnosis and timely treatment.