The chancre is an early symptom of syphilis, and if it is not treated systematically, it may gradually disappear in more than three to four weeks, but it is not a self-cured syphilis, and there are still syphilis spirochetes in the patient’s body. The hard chancre is one of the main manifestations of stage 1 syphilis, and its development sites include the genitals, anus and mouth, etc. The main symptom is the appearance of localized pimples, erythema, hard nodules and even ulcerated surfaces, which may be only one or more than one. If the patient’s body has good resistance, the symptoms usually subside in more than 3 to 4 weeks, and there will be some small scars at the site of the noma, after which the scar tissue will gradually fade away. However, because the chancre is not treated with medication, the syphilis spirochetes are still present in the body, and in severe cases it can evolve into stage 2 syphilis. Once the chancre is detected, it is important to seek medical attention in a timely manner to avoid leaving the condition unattended, as it may become more and more serious.