Typical chancre in women is mainly caused by infection with syphilis pale spirochete in the first stage of syphilis, which is commonly found in women’s labia major and minor, vagina and cervix, usually round nodules, with clear boundaries, higher than the surface of the skin, red vesicle-like, with a small amount of exudation, with enlarged lymph nodes and no pressure pain; chancre is a typical symptom of the first stage of syphilis. If a woman has ulcers or abnormal growths on the perineum and smelly secretions, she must go to the hospital for examination and treatment to avoid delaying the treatment; if a woman is diagnosed with syphilis, she should first go to the hospital for standardized treatment; she should have a regular review after the treatment, and she should forbid sexual intercourse during the treatment period, and her sexual partners should also be examined and treated.