Stage I syphilis chancre occurs in the skin and mucous membranes around the genitals and anus, forming painless ulcers, and there are usually no systemic symptoms. Syphilis is a chronic, systemic sexually transmitted disease caused by infection with the spirochete syphilis and is divided into three stages. Stage I syphilis chancre is commonly found in the coronal groove of the penis, glans, prepuce and ligament in men, and in the labia majora and minora, perineum and cervix in women. The typical presentation of stage 1 syphilis noma is a small erythematous spot that rapidly develops into a painless inflammatory papule, which enlarges within a few days to form a hard nodule with necrosis on the surface, forming a single 1-2 cm diameter, round or oval, painless ulcer with clear borders, peripheral oedema and elevation, and a fleshy red base, which is cartilaginous and hard to the touch, and with a buccal secretion on the surface. It is advisable to seek prompt medical attention and active treatment if stage I syphilis noma is detected. Because the untreated or incomplete treatment of the chancre of stage I syphilis will be transformed into stage II syphilis, causing damage to the skin and mucous membranes and systemic damage, do not unauthorized use of medication, in order to avoid adverse consequences.