The appearance of the hard chancre is characterized by a red blotchy rash or papule, a hard texture, a slightly sunken center, a slightly elevated periphery and clear borders, which can be constantly changing. The chancre is the main symptom of stage 1 syphilis, and its appearance is characterized by a large number of features that can change constantly. Typically, the chancre begins as a small, reddish rash or papule on the penis and glans in men and on the labia and perineum in women. The chancre then becomes a hard, well-defined, round or oval red rash. The hard chancre is slightly depressed in the center and is accompanied by painless ulcers and erosions, but is slightly elevated at the periphery and may have a plasma discharge on the surface. Typically, an untreated chancre may persist for 3 to 4 weeks, and in patients who take treatment measures, the chancre subsides after 1 to 2 weeks, but localized hyperpigmentation or scarring may remain. Syphilis is a chronic systemic sexually transmitted disease (STD) caused primarily by infection with the spirochete syphilis. When patients are detected with chancre, they need to actively cooperate with doctors to avoid delaying the condition.