The mainstay of treatment for patients with chancre is medication. The most commonly used drugs are penicillin and cephalosporin. Penicillin is the drug of choice. Commonly used is benzathine penicillin 2.4 million U, divided into two sides of the buttocks intramuscular injection, use 1~3 times; or procaine penicillin G and aqueous penicillin G 1.2 million U intramuscular injection, continuous 10~14 days.
Ceftriaxone has proven to be a highly effective anti-TP (syphilis spirochete) drug in recent years and can be used as the drug of choice for those allergic to penicillin, using 1.0-2.0g/day intramuscularly or intravenously for 10-14 days. Tetracyclines and macrolides are less effective than penicillin and are usually used as alternative therapeutic agents for penicillin-allergic patients, usually also requiring 14 consecutive days of oral administration.