If the fetus has malformation, it can be detected by NT examination at 10~14 weeks of pregnancy or 4D ultrasound examination at 18~24 weeks of pregnancy. At 10~14 weeks of pregnancy, NT examination is needed to observe the thickness of the fetal posterior nuchal translucency, and if it is too thick, it indicates the possibility of Down’s syndrome; at 18~24 weeks of pregnancy, 4D ultrasound examination is needed to judge the physiological structure of the fetus through the three-dimensional clear image, and to observe whether there is any malformation in the fetus. It is recommended that pregnant women conduct adequate pregnancy checkups during pregnancy to protect the health of the fetus, in addition to glucose tolerance test, fetal heart monitoring, etc., and if there are abnormalities, they should consult a doctor in a timely manner and follow the doctor’s instructions to carry out reasonable interventions.