In 1959, Prinzmetal et al. named ischemic angina caused by coronary artery spasm as “variant angina”, stating that the attack of angina is not related to activity, the pain occurs in quiet time, the ST segment of the ECG is elevated during the attack, and after the attack, the ST segment decreases without pathological Q wave. After the attack, the ST-segment decreases and no pathological Q waves appear. Myocardial infarction and death occur more frequently within six months. Variable angina can lead to acute myocardial infarction and severe arrhythmias, even ventricular fibrillation and sudden death. Variable angina is a condition in which there are significant symptoms of angina and the ECG shows a transient arch-back upward ST-segment elevation, and after the angina subsides, the ST-segment rapidly falls back to baseline. Anginal symptoms often occur at rest and have no relationship with physical work or emotions. The cause of variant angina is vasospasm, and in a small number of patients, sustained, severe spasm of the coronary arteries can also cause myocardial infarction or even sudden death. Commonly used drugs for the treatment of variant angina are calcium antagonists such as nifedipine, amlodipine, diltiazem, and also nitroglycerin. Variable angina is also a type of coronary artery disease, and long-term use of secondary prevention drugs for coronary artery disease, such as aspirin, simvastatin, and enalapril, is recommended. Since the vasodilating effect of beta receptors is blocked and the constricting effect of alpha receptors is relatively enhanced when beta blockers are used, which may induce and aggravate arterial spasm, the application of beta blockers is generally not advocated.