The surgery cost of melanoma usually ranges from several tens of thousands of dollars, and the charges of different hospitals vary greatly, so it is recommended to consult the local hospital for the specific cost. Melanoma has a high degree of malignancy, mostly metastasizes and has a poor prognosis. Therefore, early diagnosis and timely and reasonable treatment are extremely important. Early local surgical resection is the best way to strive for a cure, and the principle of resection is based on the standard of no local recurrence. The cost of treatment is closely related to the stage of the disease, the timing of treatment, surgical methods, treatment strategies, and the patient’s own physical condition, and the charges of different hospitals vary greatly, usually ranging from tens of thousands of dollars. If radiotherapy and chemotherapy are used at a later stage, the cost of a course of treatment ranges from 20,000 to 30,000 yuan. It is recommended that patients ask local hospitals for prices as a reference when undergoing surgery for in situ melanoma of the thumb of the hand.