The most common pains of pancreatic cancer patients are two major categories, namely pain and inability to eat due to vomiting after eating. Pain in pancreatic cancer patients is a manifestation of cancer pain. Severe pain can affect patients’ quality of life and make them suffer, which can be treated with analgesic therapy, according to WHO three-step analgesic treatment principle, i.e. non-steroidal anti-inflammatory analgesics, such as aspirin and fen-phen, can be used for mild pain, and weak opioid analgesics, such as tramadol and tylenol, can be used for moderate pain. For severe pain, strong opioid analgesics, such as morphine and oxycodone, may be used. The goal of pain management is for the patient to feel no or only mild pain and to sleep peacefully at night. If the patient is unable to eat, a gastric tube, jejunostomy tube or fistula should be inserted to enable enteral nutrition, improve the quality of life and reduce pain. In addition, some patients with pancreatic cancer will have tumor compression of the bile ducts, resulting in progressive worsening of jaundice. Patients may have symptoms such as generalized yellow staining, skin itching, nausea and vomiting, which are painful. In order to relieve patients’ pain, bile duct stenting can be performed to open the bile ducts and unblock the bile ducts, or external bile duct drainage can be performed to drain the blocked bile and eliminate jaundice. The most effective way to relieve the patient’s pain is to control the growth of the tumor, which can be done by chemotherapy, radiotherapy, targeted therapy and immunotherapy.