For patients with pancreatic cancer combined with duodenal metastasis, if there are no lymph nodes, distant metastasis, etc., and if they are in good physical condition, they can be treated by surgical resection to alleviate the symptoms and prolong the survival period. If pancreatic cancer with duodenal metastasis occurs, it means that it has already reached the middle or late stage, and the cancer cells have already spread and metastasized, which may lead to the symptoms of duodenal obstruction, nausea and vomiting. If the physical indications support the surgical treatment, it can be treated by surgical resection of the primary foci and metastatic foci, and combined with chemotherapy and radiotherapy to relieve the symptoms, control the continuous spread of cancer cells, and prolong the survival period. If distant metastasis has already occurred, the patient’s physical condition is poor, combined with cardio-cerebral and pulmonary complications, or the life expectancy is short, surgery is usually not recommended, and radiotherapy or targeted therapy can be given. It is recommended to go to a regular hospital to evaluate the condition, choose the appropriate treatment plan, and follow the doctor’s instructions to cooperate with the treatment to improve the prognosis and quality of life, so as not to delay the condition.