The effects of thalassemia medium on children are less severe than those of thalassemia major and are closely related to the degree of anemia. If the anemia is mild, generally speaking, it does not have much effect on the child, but if it causes moderate to severe anemia, it will have a greater effect on the child, mainly including brain development, spirit, appearance, immunity and organ function. 1. Brain development: If the degree of anemia is heavy, it can affect the development of the child’s brain, and the child can usually show symptoms of dizziness and headache. If the anemia is serious, it can even affect the child’s language function, motor function, memory and intellectual development. 2. Mental aspect: thalassemia medium can cause hemolytic anemia, the child will be manifested as pale face, lips, mental depression, fatigue, accompanied by sclera yellowing and hepatosplenomegaly and other symptoms. 3. Appearance: In long-term moderate or above anemia, due to the compensatory proliferation of bone marrow, the child may present a special face with a larger head, wider eye spacing, low nose, and protruding forehead and cheeks. 4. Immunity: If the disease is more serious, it can affect the immune function of the child, which is characterized by low resistance and easy to suffer from various infectious diseases, such as respiratory tract infections and digestive tract infections. 5. Organ function: If the condition is more serious and the child needs repeated blood transfusion, it can cause iron overload in the child’s body, which affects the function of various organs, such as heart function, pancreatic function and thyroid function. Generally speaking, the condition of thalassemia medium is stable, and if it is well controlled, it will not have much effect on the child’s daily life. It is recommended to strictly follow the doctor’s instructions, go to the hospital for rechecking regularly, keep a good mood in the day-to-day life, avoid laborious work, have a balanced diet, and improve one’s own quality.