Cafe au lait spots on children’s bodies should be excluded from potential genetic diseases first, depending on the situation, observation treatment or laser treatment. 1. Excluding potential genetic diseases: cafe-au-lait spots are the characteristic clinical manifestation of type I neurofibromatosis, if there are more than 6 cafe-au-lait spots with diameter>5mm, more than two neurofibromas, freckles in axillary or inguinal area, iris malformation and so on, then it is highly suspected to suffer from type I neurofibromatosis, and need to prevent and control its complications actively. 2. Treatment of cafe au lait spot: cafe au lait spot is a kind of benign pigmentation spot, which will not cause any symptom except affecting aesthetics, so it can not be treated. If you want to remove it for cosmetic reasons, you can use laser treatment, usually choose Q-tuning or picosecond laser, and it takes 4~6 times to achieve the ideal treatment effect. Parents are advised to bring their children to the hospital in time for consultation and standardized treatment under the guidance of doctors.