With the development of modern society, people’s life rhythm accelerates, and the pressure of work and life increases dramatically. The number of smokers is increasing and tends to be younger and younger. Smoking is a vice, but many people know that there is a tiger in the mountain, but to the tiger mountain. Do not know that bad luck is also coming to you. 1, smoking damage to the male reproductive system smokers sperm density than non-smokers fell 13-17%, smoking index heavy population sperm density fell more significantly. Smoking reduces sperm motility and activity rate, especially the straight-line movement of sperm. There is a dose-response relationship between changes in sperm density and sperm motility and smoking. Cigarette smoking causes an increase in sperm malformation and an increase in the proportion of head-defective sperm and ovoid sperm, as well as an increase in microdroplets in the sperm cytoplasm and an increase in the proportion of immature sperm. Cigarettes contain a large number of toxic substances such as nicotine, cotidine and cadmium. Nicotine can affect the morphology of sperm and the density of sperm. Seminal fluid levels of cotinine and 3-hydroxycotinine were negatively correlated with sperm motility, and cotinine levels were negatively correlated with sperm linear motility. There was a significant correlation between seminal plasma cotinine concentration (positively correlated with smoking) and percentage of abnormally morphologic spermatozoa. The testis is one of the major target organs for cadmium, causing hemorrhagic necrosis of some testicular tissues by damaging the blood-testis barrier, acting on chromosomes of mesenchymal cells and damaging the spermatogenic epithelium. Studies have found that exposure of sperm from nonsmokers to the seminal plasma of smokers diminishes sperm motility, acrosome response and MDA levels. Vitamin E is the most essential antioxidant in semen, and the level of vitamin E in human seminal plasma is 0-10 mg/dl, which is 9 times higher than the level in blood. Serum vitamin E levels decrease by 20-40% in heavy smokers, and semen quality can be improved with vitamin E supplementation therapy. Serum levels of zinc, copper and SOD were decreased in moderate and heavy smokers compared to nonsmokers, and were negatively correlated with the total amount and duration of smoking. Semen leukocytes were elevated by 48%, ROS levels decreased by 107%, and ROS-TAC scores decreased by 10 points in smokers. Components of cigarette smoke can induce oxidative damage to sperm DNA through the blood-testis barrier, leading to changes in semen quality. Vitamin E’s in semen correlated with sperm density, sperm motility, and percentage of normal sperm morphology. The process of smoking produces various toxic oxygen reactive substances, such as superoxide anions and oxygen radicals, which not only have a damaging effect on blood vessels, affect testicular blood flow, cause testicular spermatogenic dysfunction and increase malformed sperm, but also cause oxidative stress, which can cause mitochondrial and DNA damage. The above-mentioned reasons are important causes of male infertility. 2, the effect of smoking on male sexual function Nicotine can change the hypothalamic-pituitary axis, stimulating the release of growth hormone, cortisol, pressin and prolactin, which in turn inhibits the release of luteinizing hormone and prolactin. Studies have reported an increase in 17β estradiol and a decrease in luteinizing hormone, follicle stimulating hormone and prolactin in smokers. Ramlau reported a dose-response relationship between serum T, LH and LH/ free-T and smoking. People with a long history of smoking and those who smoked more than 10 cigarettes per day had higher ORs for ED (1.4 and 1.3, respectively) compared to nonsmokers, and there was a dose-duration response. Rahman reported that those who smoked since 1994 and developed vascular disease in 1994-1999 had three times the risk of ED in 1999-2004 (IDR 3.1), suggesting that smoking causes erectile dysfunction by causing vascular disease. Smoking impairs penile arterial blood flow and causes severe constriction of penile arteries, leading to the development of ED. Overall, prolonged smoking has damaging effects on the vascular endothelium, peripheral nerves, and ultrastructure of tissues, mediating the effects of chronic smoking on erectile function. More precisely, smoking increases the production of reactive groups (ROS) and reduces the biological activity of NO, leading to impaired relaxation of endothelial smooth muscle in the penis, which affects penile erection and leads to sexual dysfunction. 3, smoking can lead to urological tumors Kidney cancer is the most common renal parenchymal tumor, and the incidence and mortality rate of kidney cancer in the world accounts for about 2% of all tumors. Smokers have twice the risk of kidney cancer than never smokers, and heavy smokers have a higher incidence than light smokers, and the longer the smoking time, the higher the incidence. 4.Smoking can lead to bladder cancer. Bladder cancer is the most common malignant tumor of the urinary system, the incidence of the first of the malignant tumors of the urinary system. Studies have found that acrolein in tobacco can trigger diffuse proliferation of bladder epithelium, while tobacco contains aromatic amines and other harmful substances, mostly in the form of inactive metabolism, excreted in the urine. In this process, bladder cancer is triggered and formed due to the toxic and mutagenic effects acting on the bladder. At the same time, studies have shown that those who used to be smokers and now quit smoking have a lower risk of bladder cancer than those who are still smoking, and even heavy smokers can reduce their risk of bladder cancer if they start to quit smoking, which also shows that quitting smoking has some effect. Through this article, I hope that the article can draw the attention of smokers to quit smoking as soon as possible for themselves and their families.