Long-term use of birth control pills may have common adverse reactions, such as early pregnancy-like reactions, vaginal bleeding, menstrual bleeding or menopause, breast swelling and pain, and so on. 1. Early pregnancy-like reactions: a few women often occur in the first two cycles of the pill, such as mild nausea, loss of appetite, dizziness, fatigue, drowsiness, vomiting, etc., which can be improved after continuing to take the pill. 2. Vaginal bleeding: usually occurs in the early stage of taking the medicine, manifested as spotting bleeding or menstrual-like breakthrough bleeding. The more common reasons are partly related to the fluctuation of hormone levels in some women’s bodies at the early stage of taking the medicine, and the other common reasons are missed dose, irregular dose, wrong way of taking the medicine or impaired quality of the medicine, and so on. It can be handled under the guidance of physician’s examination. 3. Decrease in menstrual flow or stoppage of menstruation: this is because the compound oral contraceptive pill will inhibit the proliferation of the endometrium, resulting in a decrease in menstrual flow or stoppage of menstruation. Decrease in menstrual flow generally does not need to be treated because it does not affect health and returns to normal by itself after stopping the pill. For women who have stopped menstruating, pregnancy needs to be ruled out. If the user really can not accept the decrease in menstrual flow or menopause, according to the specific circumstances, can stop using or change to other contraceptive methods. 4. Breast swelling and pain: generally do not need to be treated, with the prolongation of the duration of the drug, the symptoms may disappear on their own. It is recommended to use the medication properly under the guidance of a doctor and seek medical advice promptly if you feel unwell.