Thyroid adenoma with cystic change is an ultrasound term that generally refers to a thyroid adenoma that presents with cystic changes that may suggest a benign neoplastic lesion. Thyroid adenomas with cystic changes are generally benign tumors. The etiology and pathogenesis of the disease are not clear, but they are associated with endocrine, radiological, gender, dietary and other factors. The course of the disease is slow and most patients have no conscious symptoms. With the development of the disease, the lump will grow gradually and painless lumps will appear in the neck of the patients, and due to the compression of the lumps on the neighboring tissues, there will be discomfort in swallowing, dyspnea, and hoarseness, etc. The disease is also characterized by the presence of cancerous thyroid adenomas and cystic changes. Since thyroid adenomas have the risk of becoming cancerous, once the diagnosis is confirmed, surgery should be performed as soon as possible to remove the tumor. It is recommended that patients seek timely medical advice and follow the doctor’s instructions for standardized treatment.