Disturbed and peculiar behavior is one of the clinical manifestations of mental disorder associated with intracranial tumor. Mental disorder associated with intracranial tumor refers to mental disorder associated with the invasion of brain parenchyma by intracranial tumor and compression of adjacent brain tissues or cerebral vessels, resulting in destruction of brain parenchyma or increase of intracranial pressure. Detailed neurological examination is an important factor to prevent misdiagnosis. In addition to EEG, CT, MRI and other examinations to confirm the diagnosis, chest X-ray should be taken to find the primary focus of metastatic cancer. What are the prevention methods of mental disorder associated with intracranial tumor? 1.Changing the scope of organic lesion, solving the problem from the source and preventing mental disorder. 2.Patients with diagnosed brain tumor should be given more social and family psychological support and assistance, which is expected to reduce the symptoms of brain tumor associated mental disorder. The psychological care of mental disorder patients is extremely important. Family members should not dislike the patients, but encourage them to establish confidence to overcome the disease and dispel the negative thoughts of patients. 4, grasp the characteristics of mental disorder patients and the situation of the mind, the patient to do a good job, pay attention to the custody of dangerous goods, do not let the patient go out alone, often check the patient’s body and bed whether there are dangerous goods or the patient wrote a suicide note and note to prevent patients accumulate a large number of drugs swallowed at once and caused by suicide. Early detection and early treatment is the principle of treatment for all diseases, and the treatment of intracranial tumor is no exception. The earlier the treatment, the better the effect. Treatment methods include surgery, radiotherapy, chemotherapy, Chinese herbal medicine, immunotherapy, etc. Anti-psychotic drugs with high efficiency and low toxic side effects should be selected for psychiatric symptoms. The dose of medication should not be too high, especially in the postoperative period and in radiotherapy and chemotherapy, and patients with epilepsy should monitor the blood concentration. It is important to maintain a relatively calm state of mind. This requires young people to face reality and unite their personal ideological wishes and requirements with the real society.