Thick yellow sputum in the throat in the morning is most commonly associated with a clinical inflammatory response of the respiratory system, mainly caused by a purulent bacterial infection. It is common to have acute pharyngitis, acute attack of chronic pharyngitis, acute attack of chronic bronchitis, acute bronchitis, etc. Moreover, the mucous membrane of the respiratory tract is exuding inflammatory secretions in a yellow-purulent color due to purulent bacteria. Clinically, you can choose antibiotics that resist bacteria to treat, such as the first choice of penicillin, amoxicillin clavulanic acid potassium, clindamycin, erythromycin, levofloxacin and other drugs.