Neuroblastoma stage 4 high-risk should adopt a comprehensive treatment plan, generally is the first chemotherapy and then elective surgery, after surgery and then follow the doctor’s prescription for chemotherapy, after the end of conventional chemotherapy, feasible autologous stem cell transplantation, as well as tumor bed radiotherapy, can not be carried out for stem cell transplantation can continue to carry out chemotherapy. Neuroblastoma is a very heterogeneous tumor disease, according to INSS staging can be divided into stage 1, 2, 3, 4 and 4s. Neuroblastoma stage 4 is the primary tumor with distant lymph nodes, liver, skin, bone marrow and other organs dissemination, and according to the risk level can be divided into low-risk, medium-risk and high-risk neuroblastoma. According to the consensus of the relevant experts on the treatment of this disease, for stage IV high-risk neuroblastoma, chemotherapy is usually given for about 4 courses before elective surgical treatment. In addition, conventional chemotherapy should be carried out after surgery, and then autologous stem cell transplantation and tumor bed radiotherapy should be carried out after the end of conventional chemotherapy, and tumor bed radiotherapy should be carried out between two autologous stem cell transplants. If autologous stem cell transplantation is not possible, chemotherapy may be given. Children are the main incidence of neuroblastoma, so parents should pay attention to their children’s health status and seek medical treatment in time if they find any abnormality.