Significant pain in the right calf muscle is considered to be caused by venous thrombosis of the lower extremity, and the painful symptoms are aggravated when the patient performs foot dorsiflexion. Venous thrombosis is commonly caused by injury to the intima of the blood vessel, secondary to the local deposition of platelets, which will eventually affect the blood return to the distal veins, and will result in swelling of the limb, even with obvious tension blisters, accompanied by fever. During the acute phase, the affected limb should be elevated to be able to prevent thromboembolism and promote venous blood return, and anticoagulation therapy should be actively carried out with the application of low molecular heparin calcium subcutaneous injection. During the treatment period, attention should be paid to the prevention of infection, and some patients are prone to the occurrence of femoral cyanosis, which should be prevented.