In the outpatient clinic, we often find that pregnant mothers will be confused with Down’s screening and sugar screening, mainly because the pronunciation is the same and both are important screening programs during pregnancy, so here is a brief introduction: 1, the examination time is different: Down’s screening (Down’s screening): 15-20 weeks of pregnancy Sugar screening (diabetes screening): 24-28 weeks of pregnancy 2, the purpose of the examination is different: Down’s screening: to understand the risk value of fetal chromosomal abnormalities, if the results are If the result is high risk of Down’s syndrome, further amniocentesis is needed for fetal chromosome examination to understand whether the fetus has trisomy 21 or trisomy 18. If the result is low risk for Down’s syndrome, the risk of fetal chromosomal abnormalities is low and amniocentesis is not necessary. Diabetes screening: To find out whether the pregnant woman has gestational diabetes, if she has gestational diabetes, she needs to consult her obstetrician and nutritionist for blood glucose monitoring, diet adjustment, weight control, etc. 3, the examination method is different: Down’s screening only once fasting blood; diabetes screening (OGTT) to draw blood three times: fasting blood (fasting 10-12 hours) once, then drink 50% glucose solution 150ml, drink within 5 minutes, 1 hour and 2 hours after each blood draw. Food could be taken only after three blood draws. The results were: fasting blood glucose 5.1mmol/L, 1 hour blood glucose 10.0mmol/L, 2 hours later blood glucose 8.5mmol/L, any one of these values is higher than normal, the diagnosis of gestational diabetes.