Gout when the toes are swollen and painful is the manifestation of the acute attack period, the specific treatment is as follows: 1, non-steroidal anti-inflammatory drugs: more commonly used is etoricoxib tablets, this drug is a COX-2 specific inhibitors, the general gastrointestinal reaction is relatively small, but if there is an active peptic ulcer, it is generally not recommended to use this type of drug. 2, colchicine: this drug is the treatment of gouty arthritis in the acute attack period of the first-line drugs, but this drug has a certain degree of intestinal toxicity, and the higher the dose of high intestinal toxicity, the higher the probability of diarrhea. However, this drug has a certain degree of enterotoxicity, and the larger the dose, the higher the enterotoxicity, the greater the probability of diarrhea, if there is a serious diarrhea should be discontinued immediately. 3, glucocorticoids: If the therapeutic effect of non-steroidal anti-inflammatory drugs and colchicine is not good, or intolerable, you can choose to glucocorticoid therapy. Generally, the medium-acting glucocorticosteroids, such as methylprednisolone tablets or prednisone, if the effect is not good, you can choose the long-acting glucocorticosteroids, such as dexamethasone, etc. for treatment.