Widening of the aortic sinus to narrow is generally only treatable by surgery. However, if it is only widening but not to the extent of aortic aneurysm, surgical treatment is not required, but rather, the primary cause of the widening of the aortic sinus should be treated to slow down the progress of the disease. Clinically, the main causes of aortic sinus widening are congenital developmental anomalies, hypertension, aortic atherosclerosis and so on. 1. Congenital developmental anomalies: common in patients with equine syndrome, asymptomatic or symptoms are not serious, do not need special treatment, regular review can be, if there is myocardial ischemia, angina pectoris, aortic regurgitation and so on, need to carry out surgical treatment. 2. Hypertension: Long-term poor control of hypertension can easily lead to decreased aortic elasticity and widening of the aorta, which needs to be actively treated with antihypertensive drugs, such as diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin 2-receptor antagonists, β-blockers and so on. 3. Aortic atherosclerosis: Atherosclerosis involves the aorta leading to aortic widening, which needs to be treated by lipid regulating drugs, such as atorvastatin; anticoagulant drugs, such as warfarin; antiplatelet drugs, such as aspirin, etc. to stabilize atherosclerotic plaque. Diseases that can promote atherosclerosis, such as diabetes, should also be controlled. After the widening of the aorta, it may react with smaller coronary openings and insufficient blood supply to the coronary arteries: incomplete closure of the aortic valve and blood regurgitation; as well as aortic aneurysm, coarctation of the aorta and other complications, so it is important to find out and treat it as early as possible, so as to avoid delaying the condition, which may cause adverse consequences.