Acute tonsillitis in serious condition need to be treated with antibiotics intravenous infusion, commonly used cephalosporins or penicillin antibiotics, if the local swelling is more obvious, you can use glucocorticosteroid treatment as appropriate. 1. Antibiotics: preferred penicillin antibiotics, such as: amoxicillin, ampicillin, etc.; according to the results of the skin test using cephalosporin antibiotics, such as: ceftriaxone, cefadroxil and other drugs, or choose macrolides, such as: azithromycin and so on. If the condition does not improve after 2-3 days of treatment, the cause must be analyzed and other kinds of antibiotics must be used. 2. Hormone: when the swelling of the pharynx is obvious, dexamethasone or methylprednisolone sodium succinate can be used for intravenous treatment. Avoid spicy and stimulating food during treatment, avoid alcohol when using cephalosporin drugs, and follow the doctor’s instructions to standardize the use of drugs.