The most common one is depression. One of the three core symptoms of depression is feeling tired and fatigue, which cannot be relieved by rest. Secondly, we need to consider whether the patient has reduced thyroid function, hypothyroid patients can also appear generalized fatigue, tiredness. Third, the patient’s sleep condition is not good, long-term poor sleep, can not get enough rest, can also appear fatigue, tired phenomenon. Fourthly, if the patient has hypokalemia, if excessive sweating leads to hypokalemia and muscle fatigue, generalized fatigue and tiredness can also occur.