In the late stage of SLE, different symptoms may appear due to the involvement of different organs, which may be manifested as symptoms of cardiac, renal, neurological and other systemic involvement.
1. Heart: When SLE involves the heart, pericarditis, myocarditis and endocarditis may occur. The main manifestations are chest pain, fatigue, palpitation, etc. Electrocardiogram and cardiac enzyme spectrum examination may show different degrees of elevation.
2. Kidney: When SLE is combined with nephritis, there will be hematuria, elevated blood pressure, edema and other manifestations, and the symptoms of uremia will appear in the late stage. Patients with SLE combined with nephrotic syndrome will have different degrees of edema, accompanied by abdominal, pleural or pericardial effusion, and laboratory tests will show a large amount of proteinuria, lowered serum albumin, and elevated blood lipids.
3. Neurology: SLE involving the nervous system can lead to lupus encephalopathy, which can be manifested as headache, epileptic seizure, intracranial hemorrhage, movement disorder and other symptoms.
It is recommended that SLE patients go to the rheumatology and immunology department of regular hospitals for consultation, standardized diagnosis and treatment under the guidance of doctors, and regular follow-up.