Total body paralysis and inability to speak is considered to be caused by brain lesions, common such as brain tumor, encephalitis, cerebrovascular disease and so on. 1. Brain tumor: Brain tumor is a tumor or brain metastasis originating from intracranial tissues. The etiology is not yet clear and may be related to ionizing radiation, heredity and so on. If the tumor is in the frontal lobe, it may lead to contralateral hemiparesis, and persistent paralysis if not treated in time, and eventually accompanied by aphasia and increased intracranial pressure and other symptoms. 2. Encephalitis: encephalitis is caused by pathogens infecting the brain parenchyma, and in the late stage of encephalitis, different types of paralysis may occur, and some patients may also have fever, headache, aphasia and epilepsy. 3. Cerebrovascular diseases: such as cerebral hemorrhage, cerebral infarction and so on, leading to cerebral tissue ischemia, hypoxia, necrosis, which may lead to contralateral hemiparesis, and the symptoms of not being able to speak will appear when the language center is involved. There are many reasons for general paralysis and inability to speak, so it is recommended that family members take the patient to the doctor in time for relevant examinations to make a clear diagnosis.