Frictional irritation and contact allergies are the most common causes of eczema in the knee area, while food allergies, for example, can also cause eczema changes in the knee or other parts of the body. The main clinical manifestations are erythema and papules in the knee area with significant itching, and in severe cases, blisters, vesicles, and oozing. In severe cases, blisters, vesicles, and oozing may occur. If there is a combination of infection, pus may also develop. Depending on the severity of the rash, oral or topical treatment is required, with commonly used oral medications such as loratadine or cetirizine hydrochloride. Local if there is vesicles, exudation, you can use 3% boric acid solution wet compress, to vesicles, dry local can be applied topical hormone cream, such as mometasone furoate cream, etc., usually pay attention to avoid friction stimulation.