A positive P16 cervical biopsy means that the cervix is immunohistochemically positive for P16. If there is no cervical pre-cancer or cervical cancer, it can be observed, but if there is a cervical pre-cancer or cervical cancer, the patient needs to be treated with surgery as well as radiotherapy. A positive cervical immunohistochemistry for P16 usually indicates that the patient has human papillomavirus type 16 infection, which suggests that the patient has a higher risk of developing cervical cancer. Patients who do not have cervical pre-cancer or cervical cancer may be left untreated, but should be seen regularly for follow-up. If the patient has precancerous cervical lesions or early cervical cancer, surgical treatment can be taken, and if the patient has intermediate or advanced cervical cancer, surgery, radiotherapy, chemotherapy, targeted therapy and other integrated treatments are needed. It is suggested that patients with p16-positive cervical biopsy need to consult a doctor in time, and the doctor will judge the condition according to the examination result and take appropriate measures for treatment.