Cold knee pain can be caused by cold, osteoarthritis, rheumatoid arthritis, vascular disease, etc. It can be treated with general, physical, chemical and surgical treatments. 1. Cold: Cold weather or thin clothing can lead to cold in the knee area. When stimulated by cold, the local blood vessels in the knee will contract and the blood circulation will be poor, which can cause cold pain and discomfort in the knee. You need to pay attention to keep your knees warm, wear more clothes when the weather is cold, cover up when you sleep, and wear knee pads to keep your knees warm if necessary. 2. Osteoarthritis: degeneration and wear and tear of articular cartilage in the knee, resulting in localized aseptic inflammation, cold stimulation and excessive weight bearing can occur when the knee cold pain symptoms. It is necessary to consult a doctor in time, to be ibuprofen and other analgesic treatment, can be injected into the joint cavity lubrication of sodium hyaluronate, if necessary, feasible surgical treatment. 3. Rheumatoid arthritis: when the knee joint is involved, it can lead to the deposition of local immune complexes and synovial lesions in the joints, which can cause cold knee pain. It is necessary to consult a doctor in time, can follow the doctor’s instructions oral ibuprofen pain, the application of methotrexate and other immunosuppressants for treatment. 4. Vascular diseases: vascular diseases such as occlusive vasculitis of the lower extremities can affect the blood circulation of the lower extremities, causing cold pain in the knee area. Need to strictly quit smoking, moderate warmth, oral aspirin and other anti-platelet drugs and prostaglandins and other vasodilators, if necessary, surgery. When the knee cold pain should be timely medical treatment, under the guidance of the doctor early appropriate treatment, in favor of reducing pain and other discomfort symptoms.