Pyloric masses should be differentiated from various diseases such as improper feeding, systemic or localized infections, pneumonia and congenital heart disease, central nervous system diseases that increase intracranial pressure, progressive renal disease, infectious gastroenteritis, various intestinal obstructions, endocrine diseases, and gastroesophageal reflux and esophageal hiatal hernia. 1.Intestinal obstruction The obstruction to the passage of intestinal contents caused by any cause is collectively called intestinal obstruction. It is one of the common surgical emergency abdominal diseases. Sometimes acute intestinal obstruction is difficult to diagnose, and the condition develops rapidly, often leading to the death of patients. The current mortality rate is generally 5% to 10%, and 10% to 20% for those with strangulated intestinal obstruction. Water, electrolyte and acid-base balance imbalance, as well as the patient’s age combined with cardiopulmonary insufficiency are often the cause of death. 2. Infectious gastroenteritis is an infectious disease of the gastrointestinal tract that causes vomiting and diarrhea. 3. Pneumonia is an inflammation of the terminal airways, alveoli and interstitial lungs, which can be caused by disease microorganisms, physicochemical factors, immune damage, allergies and drugs. Bacterial pneumonia is the most common form of pneumonia and one of the most common infectious diseases. 4, congenital cardiovascular disease is the most common type of congenital malformation. In mild cases, it is asymptomatic and found during physical examination. In severe cases, there may be dyspnea, cyanosis and syncope after activity, and in older children, there may be growth retardation. Neonatal heart failure is considered an emergency and is usually mostly due to a more severe heart defect in the child. Its clinical manifestations are due to congestion of the pulmonary circulation, body circulation, and reduced cardiac output.