The causes of enlarged mesenteric lymph nodes include inflammation, tumor metastasis, etc. After clarifying the cause of the disease, the symptoms can be improved by medication or surgery. 1. Inflammation: mesenteric lymph node enlargement caused by inflammation stimulation can be treated with antibiotics such as cefuroxime, roxithromycin and other antibiotics, or intravenous levofloxacin, ceftriaxone sodium, clindamycin and other antibiotics. 2. Tumor metastasis: malignant tumors can spread to mesenteric lymph nodes through lymphatic metastasis. Surgery, radiotherapy, chemotherapy and targeted therapy can be chosen according to the condition and other comprehensive anti-tumor treatment measures. Due to the individual differences and the diversity of causes, there is no absolute safest and most effective drug, it is recommended to choose the most suitable drug for yourself under the guidance of your doctor and in combination with your own situation. Adverse reactions should be treated by a doctor, and the drug is prohibited for those who are allergic to the drug.