Gastroesophageal reflux disease (GERD) refers to a disease caused by the reflux of stomach and duodenal contents into the esophagus, which can lead to inflammation, erosion, ulceration and even cancer of the gastroesophageal mucosa. Its typical symptoms are gastrointestinal symptoms such as acid reflux, regurgitation, heartburn, belching, abdominal distension, etc. It can also present with extra-esophageal manifestations such as cough, coughing sputum, tightness in the throat, wheezing, aspiration pneumonia, non-cardiogenic chest pain, reflux pharyngitis, rhinitis, otitis media, etc., which seriously affect the quality of life of patients. In particular, many patients who have been misdiagnosed as having “asthma” for a long time are actually suffering from GERD. Gastroesophageal reflux disease is a common disease, with 7%-15% of people in the Western population having GERD symptoms. China in 1999 in Beijing, Shanghai two flow investigation shows that the incidence of symptoms is 8.97%, and there is a trend of increasing year by year. (1) Gastroesophageal phase: for the contents into the esophagus, causing symptoms such as heartburn, chest pain, back pain, belching, and difficulty swallowing. (2) pharyngeal gas: the reflux reaches the throat, causing throat pain, pharyngeal foreign body sensation, hysteria, hoarseness, etc. (3) Oral-nasal cavity phase: The reflux reaches the mouth, nasal cavity, and middle ear, causing symptoms such as oral ulcers, runny nose, post-nasal drip, sneezing, nasal congestion, tinnitus, and hearing loss. (4) Laryngotracheal phase: the refluxed material enters the trachea, causing coughing, coughing, breath-holding, asthma, aspiration pneumonia, pulmonary fibrosis, etc. The symptoms in this phase are the most severe and seriously affect the patient’s quality of life, and laryngospasm may even occur to endanger the patient’s life.