Depression in college students is very common and clinicians will give different treatment advice when dealing with depression in college students depending on its severity. For patients with mild depression, they can choose to intervene using psychotherapy or physical therapy. It is well known that every university now has a counselor and one can seek the help of the school counselor to get rid of the negative emotions caused to them. If the depression has reached a moderate level and above, it is necessary to resort to medication. If the college student has reached the age of 18, there are relatively more varieties of medications to choose from. If the child is under 18 years old, there are relatively fewer varieties of medications to choose from. In China, sertraline and fluvoxamine are available with clinical data for children under 18 years of age and have a high safety factor. And abroad, fluoxetine and escitalopram are also recommended as first-line drugs for depression treatment.