Sepsis, collectively known as septicemia, is a systemic inflammatory reaction caused by toxins produced by pathogenic bacteria that multiply in the bloodstream. In newborns, there is no definite chance of cure, but it depends on the condition of the child. If the underlying conditions of the newborn are good, the immunity is normal, there are no serious complications, detection and treatment are timely, and early intravenous combination of drugs, the cure rate is relatively high, and most of the children have no problems. In patients with relatively poor resistance, premature birth, complications, and untimely treatment, such as preterm birth, congenital immunodeficiency, osteomyelitis or meningitis, and other organ damage, combined with severe complications in the newborn, the healing power will be reduced. Therefore, when considering a newborn with sepsis, it is necessary to seek prompt medical attention to clarify the type of infection and target anti-infective and other treatments to improve the chances of cure.