Dry syndrome is better treated in the early stage, mainly with immunosuppressants or immunomodulators, currently the more commonly used drugs are hydroxychloroquine and total white peony glycosides, if the involvement of important organs, such as the combination of interstitial lung fibrosis, or the combination of renal tubular acidosis, can be combined with glucocorticoid therapy. Dry syndrome is an autoimmune disease, mainly affecting exocrine glands, clinically manifested as dry mouth and dry eyes, many patients will be accompanied by flaky tooth loss, and some patients will have a history of recurrent parotid gland enlargement. The specific pathogenesis of dry syndrome is not very clear, some patients may have hyperglobulinemia, which is mainly manifested as skin rash, and other manifestations such as arthralgia and fatigue may also occur.