Pimples, or acne, on both sides of the cheeks can be caused by excessive sebaceous gland secretion, abnormal keratinization of the cells around the hair follicles, and Propionibacterium acnes infection. 1. Excessive secretion of sebaceous glands: Excessive secretion of sebaceous glands may be caused when the androgens in the body are strong, and the secretion of sebaceous glands is not discharged in a timely manner, which may lead to acne on both sides of the cheeks. 2. Abnormal keratinization of perifollicular cells: Abnormal keratinization of perifollicular cells may lead to smaller and narrower follicle openings, which may affect the discharge of sebaceous glands and clog pores, resulting in acne on both sides of the cheeks. 3. Propionibacterium acnes infection: the presence of Propionibacterium acnes infection can lead to an inflammatory reaction in the hair follicles and their surrounding tissues, which can also lead to acne on both sides of the cheeks. If you have acne on both sides of your cheeks, it is recommended that you go to the hospital in time to find out the cause of the problem and then follow the doctor’s instructions for treatment.